Product Data Sheet
IDO1/TDO-IN-8
Catalog No. A75744
IDO1/TDO-IN-8 is a dual inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO) with the ability to penetrate the blood-brain barrier. It exhibits EC50 values of 0.33 μM for IDO1 and 1.78 μM for TDO, effectively reducing the kynurenine/tryptophan ratio by modulating the kynurenine pathway of tryptophan metabolism. This compound demonstrates neuroprotective properties, alleviating motor dysfunction and mitigating depressive symptoms, making it a valuable tool in the investigation of neurodegenerative disorders such as Parkinson's disease co-occurring with depression.
Chemical Information
| Catalog Num | A75744 |
|---|---|
| M. Wt | 278.37 |
| Formula | C17H14N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3085413-22-2 |
| Synonyms | |
| SMILES | CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1 |
Biological Activity
| Description | IDO1/TDO-IN-8 is a dual inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO) with the ability to penetrate the blood-brain barrier. It exhibits EC50 values of 0.33 μM for IDO1 and 1.78 μM for TDO, effectively reducing the kynurenine/tryptophan ratio by modulating the kynurenine pathway of tryptophan metabolism. This compound demonstrates neuroprotective properties, alleviating motor dysfunction and mitigating depressive symptoms, making it a valuable tool in the investigation of neurodegenerative disorders such as Parkinson's disease co-occurring with depression. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
