Product Data Sheet
Enasidenib-d6
Catalog No. A75803
Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms.
Chemical Information
| Catalog Num | A75803 |
|---|---|
| M. Wt | 479.41 |
| Formula | C19H11D6F6N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2095569-76-7 |
| Synonyms | AG-221-d6 |
| SMILES | [2H]C([2H])([2H])C(C([2H])([2H])[2H])(O)CNC1=NC(NC2=CC=NC(C(F)(F)F)=C2)=NC(C3=CC=CC(C(F)(F)F)=N3)=N1 |
Biological Activity
| Description | Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
