Product Data Sheet
Mutant IDH1-IN-3
Catalog No. A75813
Mutant IDH1-IN-3 is a selective allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), demonstrating an IC50 of 13 nM specifically for the R132H IDH1 variant. By inhibiting this enzyme, Mutant IDH1-IN-3 effectively reduces the production of D-2-hydroxyglutaric acid (2HG) in cellular models. This compound is particularly valuable in cancer research, providing insights into metabolic alterations and therapeutic strategies targeting IDH1 mutations.
Chemical Information
| Catalog Num | A75813 |
|---|---|
| M. Wt | 366.50 |
| Formula | C22H30N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1648909-73-2 |
| Synonyms | |
| SMILES | OC1=C(CN2C=CN=C2)C=C(C(C)(C)CC(C)(C)C)C=C1CN3C=CN=C3 |
Biological Activity
| Description | Mutant IDH1-IN-3 is a selective allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), demonstrating an IC50 of 13 nM specifically for the R132H IDH1 variant. By inhibiting this enzyme, Mutant IDH1-IN-3 effectively reduces the production of D-2-hydroxyglutaric acid (2HG) in cellular models. This compound is particularly valuable in cancer research, providing insights into metabolic alterations and therapeutic strategies targeting IDH1 mutations. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
