Product Data Sheet
GALA
Catalog No. A75986
GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems.
Chemical Information
| Catalog Num | A75986 |
|---|---|
| M. Wt | 3032.36 |
| Formula | C136H215N33O45 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 107658-43-5 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)C)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)C)=O)CCC(O)=O)=O)N)C=2C=3C(NC2)=CC=CC3 |
Biological Activity
| Description | GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
