Product Data Sheet
DSPE-PEG2000-TCO
Catalog No. A76049
DSPE-PEG2000-TCO is a PEGylated derivative that functions as a coupling partner in click chemistry through a reverse electron-demand Diels-Alder reaction. This compound facilitates the formation of covalent linkages with tetrazine-modified biomolecules, enhancing the stability of lipid nanoparticles (LNPs) while promoting efficient mRNA encapsulation. It plays a critical role in the development of EGFR-targeted and APN-targeted mRNA-loaded LNPs, supporting receptor-mediated endocytosis, effective mRNA delivery, and intestinal epithelial transcytosis in various research applications.
Chemical Information
| Catalog Num | A76049 |
|---|---|
| M. Wt | 2000 (Average) |
| Formula | (C2H4O)nC53H99N2O12P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1480940-53-1 |
| Synonyms | |
| SMILES | O=C(OCCOCCNC(OC1CCC/C=C/CC1)=O)NCCOP(O)(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n] |
Biological Activity
| Description | DSPE-PEG2000-TCO is a PEGylated derivative that functions as a coupling partner in click chemistry through a reverse electron-demand Diels-Alder reaction. This compound facilitates the formation of covalent linkages with tetrazine-modified biomolecules, enhancing the stability of lipid nanoparticles (LNPs) while promoting efficient mRNA encapsulation. It plays a critical role in the development of EGFR-targeted and APN-targeted mRNA-loaded LNPs, supporting receptor-mediated endocytosis, effective mRNA delivery, and intestinal epithelial transcytosis in various research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
