Product Data Sheet
Lipid N2-3L
Catalog No. A76257
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) designed for the formation of supramolecular lipid nanoparticles (SMLNPs), facilitating mRNA delivery. Research demonstrates its ability to effectively deliver encapsulated genetic materials, such as luciferase reporter genes, which accumulate in lymph nodes, indicating robust entry into the immune system. Additionally, Lipid N2-3L has shown potential in cancer therapy, evidenced by its capacity to reduce tumor volume and enhance survival in an MC-38-OVA mouse colon cancer model when used alongside ovalbumin mRNA and the TLR7/8 agonist Resiquimod. This lipid is a valuable tool for advancing research in targeted drug delivery for cancer therapies.
Chemical Information
| Catalog Num | A76257 |
|---|---|
| M. Wt | 840.27 |
| Formula | C48H93N3O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2924606-55-1 |
| Synonyms | |
| SMILES | OCCN(CCO)CCCNC(OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCOC(C(CCCCCC)CCCCCCCC)=O)=O |
Biological Activity
| Description | Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) designed for the formation of supramolecular lipid nanoparticles (SMLNPs), facilitating mRNA delivery. Research demonstrates its ability to effectively deliver encapsulated genetic materials, such as luciferase reporter genes, which accumulate in lymph nodes, indicating robust entry into the immune system. Additionally, Lipid N2-3L has shown potential in cancer therapy, evidenced by its capacity to reduce tumor volume and enhance survival in an MC-38-OVA mouse colon cancer model when used alongside ovalbumin mRNA and the TLR7/8 agonist Resiquimod. This lipid is a valuable tool for advancing research in targeted drug delivery for cancer therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
