Product Data Sheet
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
Catalog No. A76779
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a quenched fluorescent peptide substrate specifically designed for matrix metalloproteinases (MMPs). This elongated MMP substrate exhibits enhanced activity against collagenases, including MMP-1, MMP-8, and MMP-13, as well as MT1-MMP, demonstrating higher specificity constants compared to its predecessor, FS-1. It is suitable for real-time quantification of MMP enzymatic activity, making it an essential reagent for studies in tissue remodeling and diseases involving MMP dysregulation. Excitation and emission wavelengths are 325 nm and 400 nm, respectively.
Chemical Information
| Catalog Num | A76779 |
|---|---|
| M. Wt | 1221.32 |
| Formula | C55H80N16O16 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 720710-69-0 |
| Synonyms | Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 |
| SMILES | C(C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)C)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC1)CCCCN)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3 |
Biological Activity
| Description | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a quenched fluorescent peptide substrate specifically designed for matrix metalloproteinases (MMPs). This elongated MMP substrate exhibits enhanced activity against collagenases, including MMP-1, MMP-8, and MMP-13, as well as MT1-MMP, demonstrating higher specificity constants compared to its predecessor, FS-1. It is suitable for real-time quantification of MMP enzymatic activity, making it an essential reagent for studies in tissue remodeling and diseases involving MMP dysregulation. Excitation and emission wavelengths are 325 nm and 400 nm, respectively. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
