Product Data Sheet
LY134046
Catalog No. A76898
LY134046 is an inhibitor of N-myristoyltransferase (NMT), primarily targeting norepinephrine N-methyltransferase in cardiovascular research. This compound produces sustained reductions in mean arterial blood pressure and heart rate without significantly altering norepinephrine concentrations in the rat brain. Notably, LY134046 does not engage with adrenergic or cholinergic receptors, indicating that its hypotensive and bradycardic effects operate independently of neurogenic tension. At a dosage of 40 mg/kg/day, LY134046 leads to significant inhibition of NMT activity in the hypothalamus and brainstem, thereby inducing central norepinephrine depletion.
Chemical Information
| Catalog Num | A76898 |
|---|---|
| M. Wt | 216.11 |
| Formula | C10H11Cl2N |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 71274-97-0 |
| Synonyms | |
| SMILES | ClC1=C2C(CCCNC2)=CC=C1Cl |
Biological Activity
| Description | LY134046 is an inhibitor of N-myristoyltransferase (NMT), primarily targeting norepinephrine N-methyltransferase in cardiovascular research. This compound produces sustained reductions in mean arterial blood pressure and heart rate without significantly altering norepinephrine concentrations in the rat brain. Notably, LY134046 does not engage with adrenergic or cholinergic receptors, indicating that its hypotensive and bradycardic effects operate independently of neurogenic tension. At a dosage of 40 mg/kg/day, LY134046 leads to significant inhibition of NMT activity in the hypothalamus and brainstem, thereby inducing central norepinephrine depletion. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
