Product Data Sheet
GKT136901
Catalog No. A76903
GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies.
Chemical Information
| Catalog Num | A76903 |
|---|---|
| M. Wt | 366.80 |
| Formula | C19H15ClN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 955272-06-7 |
| Synonyms | |
| SMILES | O=C1N(C2=CC=CC=C2Cl)NC(C1=C(C)N3CC4=NC=CC=C4)=CC3=O |
Biological Activity
| Description | GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
