Product Data Sheet
GKT136901 hydrochloride
Catalog No. A76907
GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties.
Chemical Information
| Catalog Num | A76907 |
|---|---|
| M. Wt | 403.26 |
| Formula | C19H16Cl2N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1254507-01-1 |
| Synonyms | |
| SMILES | O=C1N(C2=CC=CC=C2Cl)NC(C1=C(C)N3CC4=NC=CC=C4)=CC3=O.[H]Cl |
Biological Activity
| Description | GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
