Product Data Sheet
Thiorphan
Catalog No. A76950
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. By competitively binding to NEP, Thiorphan inhibits its activity, thereby preventing the degradation of neuropeptides such as substance P and neurokinin A. This compound is particularly relevant in neonatal brain injury research, as it can elevate levels of these neuropeptides, activate NK1 and NK2 receptors, and mitigate excessive NMDA receptor activation, thus providing neuroprotection against excitotoxicity. Additionally, Thiorphan may play a role in studying respiratory diseases through its potential to inhibit NEP-mediated bronchoconstriction.
Chemical Information
| Catalog Num | A76950 |
|---|---|
| M. Wt | 253.32 |
| Formula | C12H15NO3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 76721-89-6 |
| Synonyms | |
| SMILES | SCC(C(NCC(O)=O)=O)CC1=CC=CC=C1 |
Biological Activity
| Description | Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. By competitively binding to NEP, Thiorphan inhibits its activity, thereby preventing the degradation of neuropeptides such as substance P and neurokinin A. This compound is particularly relevant in neonatal brain injury research, as it can elevate levels of these neuropeptides, activate NK1 and NK2 receptors, and mitigate excessive NMDA receptor activation, thus providing neuroprotection against excitotoxicity. Additionally, Thiorphan may play a role in studying respiratory diseases through its potential to inhibit NEP-mediated bronchoconstriction. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
