Product Data Sheet
SCH-42354
Catalog No. A76965
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP). This compound enhances the biological activity of atrial natriuretic peptide (ANP) by preventing its hydrolysis, which is crucial for regulating blood pressure. Inhibition studies demonstrate that SCH-42354 exhibits IC50 values of 8.3 nM for leu-enkephalin and 10.0 nM for atrial natriuretic factor (ANF). Its significant antihypertensive activity makes it a valuable tool for cardiovascular research and the study of peptide regulation in clinical applications.
Chemical Information
| Catalog Num | A76965 |
|---|---|
| M. Wt | 341.49 |
| Formula | C16H23NO3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 144505-58-8 |
| Synonyms | |
| SMILES | CSCC[C@@H](C(O)=O)NC([C@@H](CS)CC1=C(C=CC=C1)C)=O |
Biological Activity
| Description | SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP). This compound enhances the biological activity of atrial natriuretic peptide (ANP) by preventing its hydrolysis, which is crucial for regulating blood pressure. Inhibition studies demonstrate that SCH-42354 exhibits IC50 values of 8.3 nM for leu-enkephalin and 10.0 nM for atrial natriuretic factor (ANF). Its significant antihypertensive activity makes it a valuable tool for cardiovascular research and the study of peptide regulation in clinical applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
