Product Data Sheet
CGS25155
Catalog No. A76973
CGS25155 is a potent inhibitor of neutral endopeptidase 24.11 (NEP 24.11) with an IC50 of 3 nM. By inhibiting NEP, CGS25155 effectively slows the degradation of the cardiac hormone atrial natriuretic peptide (ANP), demonstrating antihypertensive effects in the DOCA-salt induced rat hypertension model. This compound is valuable for research in cardiovascular diseases and the study of peptide metabolism.
Chemical Information
| Catalog Num | A76973 |
|---|---|
| M. Wt | 490.61 |
| Formula | C25H34N2O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 150126-87-7 |
| Synonyms | |
| SMILES | O=C([C@H]1NC([C@@H](CCCCCC1)CSC(C)=O)=O)N2[C@@H](C[C@H](C2)O)C(OCC3=CC=CC=C3)=O |
Biological Activity
| Description | CGS25155 is a potent inhibitor of neutral endopeptidase 24.11 (NEP 24.11) with an IC50 of 3 nM. By inhibiting NEP, CGS25155 effectively slows the degradation of the cardiac hormone atrial natriuretic peptide (ANP), demonstrating antihypertensive effects in the DOCA-salt induced rat hypertension model. This compound is valuable for research in cardiovascular diseases and the study of peptide metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
