Product Data Sheet
ZK824190 hydrochloride
Catalog No. A76998
ZK824190 hydrochloride is a selective inhibitor of the urokinase plasminogen activator (uPA), demonstrating promising potential for the treatment of multiple sclerosis. With IC50 values of 237 nM for uPA, and higher IC50s of 1600 nM and 1850 nM for tissue plasminogen activator (tPA) and Plasmin, respectively, this compound can effectively modulate pathways associated with neuroinflammation. Its oral bioavailability also supports its applicability in in vivo studies aimed at elucidating the role of uPA in various disease models.
Chemical Information
| Catalog Num | A76998 |
|---|---|
| M. Wt | 450.86 |
| Formula | C22H21ClF2N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2629177-12-2 |
| Synonyms | |
| SMILES | CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC=C2)=C(F)C=C1F)C(O)=O.[H]Cl |
Biological Activity
| Description | ZK824190 hydrochloride is a selective inhibitor of the urokinase plasminogen activator (uPA), demonstrating promising potential for the treatment of multiple sclerosis. With IC50 values of 237 nM for uPA, and higher IC50s of 1600 nM and 1850 nM for tissue plasminogen activator (tPA) and Plasmin, respectively, this compound can effectively modulate pathways associated with neuroinflammation. Its oral bioavailability also supports its applicability in in vivo studies aimed at elucidating the role of uPA in various disease models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
