Product Data Sheet
AACOCF3
Catalog No. A77096
AACOCF3, or Arachidonyl trifluoromethyl ketone, is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2), exerting its effects through slow binding interactions. This compound is capable of blocking the production of both arachidonate and 12-hydroxyeicosatetraenoic acid in platelets stimulated by calcium ionophores. Additionally, AACOCF3 has been shown to inhibit glucose-induced insulin secretion from isolated rat islets, suggesting its potential utility in studying pathways related to cardiovascular disease and metabolic regulation.
Chemical Information
| Catalog Num | A77096 |
|---|---|
| M. Wt | 356.47 |
| Formula | C21H31F3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 149301-79-1 |
| Synonyms | Arachidonyl trifluoromethyl ketone |
| SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(C(F)(F)F)=O |
Biological Activity
| Description | AACOCF3, or Arachidonyl trifluoromethyl ketone, is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2), exerting its effects through slow binding interactions. This compound is capable of blocking the production of both arachidonate and 12-hydroxyeicosatetraenoic acid in platelets stimulated by calcium ionophores. Additionally, AACOCF3 has been shown to inhibit glucose-induced insulin secretion from isolated rat islets, suggesting its potential utility in studying pathways related to cardiovascular disease and metabolic regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
