Product Data Sheet
Varespladib sodium
Catalog No. A77121
Varespladib sodium is a highly selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), exhibiting an IC50 of 9 nM. This compound demonstrates significant inhibition of sPLA2 activity in serum from multiple species, including rat, rabbit, guinea pig, and human, with reported IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively. Varespladib sodium is instrumental in studying inflammatory processes and lipid metabolism, making it valuable for research applications related to cardiovascular diseases and other sPLA2-mediated conditions.
Chemical Information
| Catalog Num | A77121 |
|---|---|
| M. Wt | 402.38 |
| Formula | C21H19N2NaO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 172733-42-5 |
| Synonyms | LY315920 sodium |
| SMILES | CCC1=C(C(C(N)=O)=O)C2=C(OCC(O[Na])=O)C=CC=C2N1CC3=CC=CC=C3 |
Biological Activity
| Description | Varespladib sodium is a highly selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), exhibiting an IC50 of 9 nM. This compound demonstrates significant inhibition of sPLA2 activity in serum from multiple species, including rat, rabbit, guinea pig, and human, with reported IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively. Varespladib sodium is instrumental in studying inflammatory processes and lipid metabolism, making it valuable for research applications related to cardiovascular diseases and other sPLA2-mediated conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
