Product Data Sheet
Efipladib
Catalog No. A77144
Efipladib is a selective inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 0.04 μM and a Kd of 0.067 μM. This compound demonstrates significant inhibition of arachidonic acid release, contributing to its potential in modulating inflammatory responses. Efipladib is valuable for research applications aimed at understanding cPLA2α-driven pathways in various disease models, including neuroinflammation and cardiovascular conditions.
Chemical Information
| Catalog Num | A77144 |
|---|---|
| M. Wt | 746.14 |
| Formula | C40H35Cl3N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 381683-94-9 |
| Synonyms | |
| SMILES | ClC1=C(Cl)C=CC(CS(NCCC2=C(CCCC3=CC=C(C(O)=O)C=C3)C4=CC(Cl)=CC=C4N2C(C5=CC=CC=C5)C6=CC=CC=C6)(=O)=O)=C1 |
Biological Activity
| Description | Efipladib is a selective inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 0.04 μM and a Kd of 0.067 μM. This compound demonstrates significant inhibition of arachidonic acid release, contributing to its potential in modulating inflammatory responses. Efipladib is valuable for research applications aimed at understanding cPLA2α-driven pathways in various disease models, including neuroinflammation and cardiovascular conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
