Product Data Sheet
Ecopladib
Catalog No. A77149
Ecopladib is a selective inhibitor of cytosolic phospholipase A2α (cPLA2α), exhibiting sub-micromolar potency with IC50 values of 0.15 μM and 0.11 μM in GLU micelle and rat whole blood assays, respectively. This compound effectively modulates the release of arachidonic acid and subsequent eicosanoid synthesis, making it a valuable tool for studying inflammatory processes. Ecopladib is applicable in research focused on the mechanisms of inflammation and related pathways.
Chemical Information
| Catalog Num | A77149 |
|---|---|
| M. Wt | 748.11 |
| Formula | C39H33Cl3N2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 381683-92-7 |
| Synonyms | PLA 725 |
| SMILES | O=C(O)C1=CC=C(OCCC2=C(CCNS(=O)(CC3=CC=C(Cl)C(Cl)=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)C=C1 |
Biological Activity
| Description | Ecopladib is a selective inhibitor of cytosolic phospholipase A2α (cPLA2α), exhibiting sub-micromolar potency with IC50 values of 0.15 μM and 0.11 μM in GLU micelle and rat whole blood assays, respectively. This compound effectively modulates the release of arachidonic acid and subsequent eicosanoid synthesis, making it a valuable tool for studying inflammatory processes. Ecopladib is applicable in research focused on the mechanisms of inflammation and related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
