Product Data Sheet
SB-435495 ditartrate
Catalog No. A77193
SB-435495 ditartrate is a potent and selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), demonstrating a remarkable IC50 of 0.06 nM. This compound functions as a reversible, non-covalent inhibitor and is suitable for oral administration. Its inhibition of Lp-PLA2 has significant implications for research in cardiovascular diseases and inflammatory processes, making it a valuable tool for investigating pathophysiological roles and therapeutic interventions in related conditions.
Chemical Information
| Catalog Num | A77193 |
|---|---|
| M. Wt | 1021.00 |
| Formula | C46H52F4N6O14S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 304694-43-7 |
| Synonyms | |
| SMILES | O=C(N(CCN(CC)CC)CC1=CC=C(C2=CC=C(C(F)(F)F)C=C2)C=C1)CN(C(SCC3=CC=C(F)C=C3)=N4)C=C(CC5=CN(C)N=C5)C4=O.OC([C@H](O)[C@@H](O)C(O)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O |
Biological Activity
| Description | SB-435495 ditartrate is a potent and selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), demonstrating a remarkable IC50 of 0.06 nM. This compound functions as a reversible, non-covalent inhibitor and is suitable for oral administration. Its inhibition of Lp-PLA2 has significant implications for research in cardiovascular diseases and inflammatory processes, making it a valuable tool for investigating pathophysiological roles and therapeutic interventions in related conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
