Product Data Sheet
GK470
Catalog No. A77221
GK470 is a potent inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. This compound exhibits significant anti-inflammatory activity by inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes, with an IC50 of 0.6 μM. GK470 demonstrates comparable anti-inflammatory effects to conventional therapies in models of arthritis and effectively reduces plasma PGE2 levels, making it a valuable tool for researching inflammatory pathways and potential therapeutic interventions.
Chemical Information
| Catalog Num | A77221 |
|---|---|
| M. Wt | 389.51 |
| Formula | C21H27NO4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1621517-53-0 |
| Synonyms | |
| SMILES | O=C(OC)C1=CSC(C(COC2=CC=C(C=C2)CCCCCCCC)=O)=N1 |
Biological Activity
| Description | GK470 is a potent inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. This compound exhibits significant anti-inflammatory activity by inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes, with an IC50 of 0.6 μM. GK470 demonstrates comparable anti-inflammatory effects to conventional therapies in models of arthritis and effectively reduces plasma PGE2 levels, making it a valuable tool for researching inflammatory pathways and potential therapeutic interventions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
