Product Data Sheet
CP-316819
Catalog No. A77225
CP-316819 is a potent inhibitor of glycogen phosphorylase (GPase), demonstrating significant antihyperglycemic activity with IC50 values of 17 nM and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa), respectively. This compound promotes glycogen accumulation under normoglycemic conditions while allowing glycogen utilization during low glucose availability. Additionally, CP-316819 has been shown to prevent neuronal cell death and sustain brain electrical activity, making it a valuable tool for research into metabolic regulation and neuroprotection.
Chemical Information
| Catalog Num | A77225 |
|---|---|
| M. Wt | 415.87 |
| Formula | C21H22ClN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 186392-43-8 |
| Synonyms | GPi 819 |
| SMILES | CON(C)C([C@H](O)[C@H](CC1=CC=CC=C1)NC(C2=CC3=CC(Cl)=CC=C3N2)=O)=O |
Biological Activity
| Description | CP-316819 is a potent inhibitor of glycogen phosphorylase (GPase), demonstrating significant antihyperglycemic activity with IC50 values of 17 nM and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa), respectively. This compound promotes glycogen accumulation under normoglycemic conditions while allowing glycogen utilization during low glucose availability. Additionally, CP-316819 has been shown to prevent neuronal cell death and sustain brain electrical activity, making it a valuable tool for research into metabolic regulation and neuroprotection. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
