Product Data Sheet
JTP-4819
Catalog No. A77285
JTP-4819 is a highly selective inhibitor of prolyl endopeptidase (PREP), exhibiting potent inhibition with IC50 values of 0.83 nM in rat brain supernatant and 5.43 nM in Flavobacterium meningosepticum. This compound demonstrates significant blood-brain barrier penetration, making it relevant for neuropharmacological studies. JTP-4819 has shown promise in enhancing memory retention in amnesia models induced by scopolamine, supporting its applications in cognitive research and potential therapeutic development for memory disorders.
Chemical Information
| Catalog Num | A77285 |
|---|---|
| M. Wt | 359.42 |
| Formula | C19H25N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 162203-65-8 |
| Synonyms | |
| SMILES | O=C(N1[C@H](C(N2[C@H](C(CO)=O)CCC2)=O)CCC1)NCC3=CC=CC=C3 |
Biological Activity
| Description | JTP-4819 is a highly selective inhibitor of prolyl endopeptidase (PREP), exhibiting potent inhibition with IC50 values of 0.83 nM in rat brain supernatant and 5.43 nM in Flavobacterium meningosepticum. This compound demonstrates significant blood-brain barrier penetration, making it relevant for neuropharmacological studies. JTP-4819 has shown promise in enhancing memory retention in amnesia models induced by scopolamine, supporting its applications in cognitive research and potential therapeutic development for memory disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
