Product Data Sheet
RAMB4
Catalog No. A77326
RAMB4 is a potent ubiquitin-proteasome system (UPS) stressor that inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activities. By triggering a UPS-stress response, RAMB4 effectively disrupts protein homeostasis without directly impacting the catalytic functions of the 20S proteasome. Its unique mechanism positions RAMB4 as a valuable tool for investigating UPS-related pathways and contributes to anticancer research by enhancing cellular stress responses.
Chemical Information
| Catalog Num | A77326 |
|---|---|
| M. Wt | 413.12 |
| Formula | C19H13Cl4NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 145888-79-5 |
| Synonyms | |
| SMILES | O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl |
Biological Activity
| Description | RAMB4 is a potent ubiquitin-proteasome system (UPS) stressor that inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activities. By triggering a UPS-stress response, RAMB4 effectively disrupts protein homeostasis without directly impacting the catalytic functions of the 20S proteasome. Its unique mechanism positions RAMB4 as a valuable tool for investigating UPS-related pathways and contributes to anticancer research by enhancing cellular stress responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
