Product Data Sheet
Cadmium pyrithione
Catalog No. A77344
Cadmium pyrithione is a metal compound that serves as a potent proteasome inhibitor, specifically targeting protein deubiquitinase activity. Its application leads to significant accumulation of ubiquitinated proteins in cancer and primary leukemia cells, contributing to its anticancer effects. By prominently inhibiting deubiquitinase activities, such as USP14 and UCHL5, Cadmium pyrithione induces apoptosis via caspase activation, while showing a lesser impact on 20S proteasome activity. Additionally, its suppression of proteasome function has been demonstrated to impede tumor growth in animal xenograft models, highlighting its potential for cancer research.
Chemical Information
| Catalog Num | A77344 |
|---|---|
| M. Wt | 364.72 |
| Formula | C10H8CdN2O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 18897-36-4 |
| Synonyms | |
| SMILES | N12[O-][Cd+2]3([O-]N4C=CC=CC4=[S]3)[S]=C1C=CC=C2 |
Biological Activity
| Description | Cadmium pyrithione is a metal compound that serves as a potent proteasome inhibitor, specifically targeting protein deubiquitinase activity. Its application leads to significant accumulation of ubiquitinated proteins in cancer and primary leukemia cells, contributing to its anticancer effects. By prominently inhibiting deubiquitinase activities, such as USP14 and UCHL5, Cadmium pyrithione induces apoptosis via caspase activation, while showing a lesser impact on 20S proteasome activity. Additionally, its suppression of proteasome function has been demonstrated to impede tumor growth in animal xenograft models, highlighting its potential for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
