Product Data Sheet
INVA8001
Catalog No. A77370
INVA8001 is a highly selective and orally active chymase inhibitor, demonstrating significant potency with IC50 values of 0.02 μM for human chymase and 0.03 μM for mouse mast cell proteinase 4 (mMCP-4). This compound exhibits remarkable selectivity over related serine proteases, with IC50 values of 3.4 μM for bovine α-chymotrypsin and 32.1 μM for human cathepsin G, showcasing over 1000-fold selectivity. INVA8001 has been shown to inhibit mast cell activity in a mouse model of primary sclerosing cholangitis (PSC), leading to improved bile duct pathology and reduced bile stasis, thus highlighting its potential anti-inflammatory and anti-fibrotic applications in research.
Chemical Information
| Catalog Num | A77370 |
|---|---|
| M. Wt | 620.09 |
| Formula | C29H38ClN5O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1312993-34-2 |
| Synonyms | ASB17061 |
| SMILES | [H][C@@]1(CN/C(CN(C1=O)C(N[C@](CCC)(C2=CC=C(C(N)=C2)C(O)=O)[H])=O)=N\OCC)CC3=C(C=CC(Cl)=C3)OC.CC(O)=O |
Biological Activity
| Description | INVA8001 is a highly selective and orally active chymase inhibitor, demonstrating significant potency with IC50 values of 0.02 μM for human chymase and 0.03 μM for mouse mast cell proteinase 4 (mMCP-4). This compound exhibits remarkable selectivity over related serine proteases, with IC50 values of 3.4 μM for bovine α-chymotrypsin and 32.1 μM for human cathepsin G, showcasing over 1000-fold selectivity. INVA8001 has been shown to inhibit mast cell activity in a mouse model of primary sclerosing cholangitis (PSC), leading to improved bile duct pathology and reduced bile stasis, thus highlighting its potential anti-inflammatory and anti-fibrotic applications in research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
