Product Data Sheet
Mitapivat hydrochloride
Catalog No. A77420
Mitapivat hydrochloride is a selective allosteric activator of pyruvate kinase R (PK-R). By enhancing the enzymatic activity of PK-R, it facilitates the conversion of phosphoenolpyruvate to pyruvate, promoting glycolysis and leading to increased ATP production in red blood cells while decreasing levels of 2,3-diphosphoglycerate. This compound shows potential for investigational studies related to pyruvate kinase deficiency and various anemia-related disorders.
Chemical Information
| Catalog Num | A77420 |
|---|---|
| M. Wt | 487.01 |
| Formula | C24H27ClN4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2559738-69-9 |
| Synonyms | AG-348 hydrochloride |
| SMILES | O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O.[H]Cl |
Biological Activity
| Description | Mitapivat hydrochloride is a selective allosteric activator of pyruvate kinase R (PK-R). By enhancing the enzymatic activity of PK-R, it facilitates the conversion of phosphoenolpyruvate to pyruvate, promoting glycolysis and leading to increased ATP production in red blood cells while decreasing levels of 2,3-diphosphoglycerate. This compound shows potential for investigational studies related to pyruvate kinase deficiency and various anemia-related disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
