Product Data Sheet
ML334
Catalog No. A77432
ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli.
Chemical Information
| Catalog Num | A77432 |
|---|---|
| M. Wt | 446.50 |
| Formula | C26H26N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1432500-66-7 |
| Synonyms | LH601A |
| SMILES | O=C(C1=CC=CC=C1C2=O)N2C[C@@H]3C4=CC=CC=C4CCN3C([C@H]5[C@H](CCCC5)C(O)=O)=O |
Biological Activity
| Description | ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
