Product Data Sheet
BRF110
Catalog No. A77486
BRF110 is a selective, orally active rexinoid that targets the Nurr1-Retinoid X Receptor alpha (RXRα) heterodimer, exhibiting an EC50 of 0.9 μM in SH-SY5Y cells. This compound upregulates brain-derived neurotrophic factor (BDNF) expression and demonstrates neuroprotective effects against MPP+-induced toxicity. Notably, BRF110 is capable of crossing the blood-brain barrier, making it a valuable tool for research in neurobiology and potential therapeutic applications in neurodegenerative diseases.
Chemical Information
| Catalog Num | A77486 |
|---|---|
| M. Wt | 413.39 |
| Formula | C22H18F3N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2095489-35-1 |
| Synonyms | |
| SMILES | O=C(O)C1=CC=C(N(C)C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C=C1 |
Biological Activity
| Description | BRF110 is a selective, orally active rexinoid that targets the Nurr1-Retinoid X Receptor alpha (RXRα) heterodimer, exhibiting an EC50 of 0.9 μM in SH-SY5Y cells. This compound upregulates brain-derived neurotrophic factor (BDNF) expression and demonstrates neuroprotective effects against MPP+-induced toxicity. Notably, BRF110 is capable of crossing the blood-brain barrier, making it a valuable tool for research in neurobiology and potential therapeutic applications in neurodegenerative diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
