Product Data Sheet
5,6-Epoxyretinoic acid
Catalog No. A77490
5,6-Epoxyretinoic acid acts as an agonist for all isoforms of retinoic acid receptors (RAR), demonstrating EC50 values of 77 nM, 35 nM, and 4 nM for RARα, RARβ, and RARγ, respectively. This compound exhibits notable growth arrest in MCF-7 and NB4 cell lines at a concentration of 1 μM. As a natural metabolite of all-trans retinoic acid, which derives from vitamin A, 5,6-epoxyretinoic acid plays a significant role in various cellular processes and research applications related to cancer biology and retinoid signaling pathways.
Chemical Information
| Catalog Num | A77490 |
|---|---|
| M. Wt | 316.43 |
| Formula | C20H28O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 13100-69-1 |
| Synonyms | 5,6-epoxy atRA; 5,6-epoxy RA |
| SMILES | CC12OC1(C(C)(CCC2)C)/C=C/C(C)=C/C=C/C(C)=C/C(O)=O |
Biological Activity
| Description | 5,6-Epoxyretinoic acid acts as an agonist for all isoforms of retinoic acid receptors (RAR), demonstrating EC50 values of 77 nM, 35 nM, and 4 nM for RARα, RARβ, and RARγ, respectively. This compound exhibits notable growth arrest in MCF-7 and NB4 cell lines at a concentration of 1 μM. As a natural metabolite of all-trans retinoic acid, which derives from vitamin A, 5,6-epoxyretinoic acid plays a significant role in various cellular processes and research applications related to cancer biology and retinoid signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
