Product Data Sheet
ES-8891
Catalog No. A77545
ES-8891 is a selective renin inhibitor that effectively reduces plasma renin activity and immunoreactive renin concentrations. In a study involving normotensive sodium-depleted macaques, administration of ES-8891 led to a significant decrease in plasma angiotensin I levels and a notable reduction in mean blood pressure, without affecting heart rate. This compound serves as a valuable tool for research on blood pressure regulation and the renin-angiotensin system.
Chemical Information
| Catalog Num | A77545 |
|---|---|
| M. Wt | 777.03 |
| Formula | C42H60N6O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 129445-88-1 |
| Synonyms | |
| SMILES | O=C(NCCCCCC)C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(CN1CCOCC1)=O)CC2=C3C=CC=CC3=CC=C2)=O)CC4=CSC=N4)=O)CC5CCCCC5 |
Biological Activity
| Description | ES-8891 is a selective renin inhibitor that effectively reduces plasma renin activity and immunoreactive renin concentrations. In a study involving normotensive sodium-depleted macaques, administration of ES-8891 led to a significant decrease in plasma angiotensin I levels and a notable reduction in mean blood pressure, without affecting heart rate. This compound serves as a valuable tool for research on blood pressure regulation and the renin-angiotensin system. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
