Product Data Sheet
SB-633825
Catalog No. A77618
SB-633825 is a potent ATP-competitive inhibitor targeting TIE2, LOK (STK10), and BRK, with IC50 values of 3.5 nM, 66 nM, and 150 nM, respectively. This compound effectively inhibits cancer cell proliferation and angiogenesis, making it a valuable tool for research on tumor growth and vascular development. Its selective inhibition profile supports studies aimed at understanding the roles of these kinases in cancer biology and therapeutic strategies.
Chemical Information
| Catalog Num | A77618 |
|---|---|
| M. Wt | 483.58 |
| Formula | C28H25N3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 956613-01-7 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2C)C(C)=C1)(C)=O |
Biological Activity
| Description | SB-633825 is a potent ATP-competitive inhibitor targeting TIE2, LOK (STK10), and BRK, with IC50 values of 3.5 nM, 66 nM, and 150 nM, respectively. This compound effectively inhibits cancer cell proliferation and angiogenesis, making it a valuable tool for research on tumor growth and vascular development. Its selective inhibition profile supports studies aimed at understanding the roles of these kinases in cancer biology and therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
