Product Data Sheet
JO146
Catalog No. A77692
JO146 is a selective inhibitor of the Chlamydia trachomatis high-temperature requirement A (CtHtrA) serine protease, exhibiting IC50 values of 21.86 μM for CtHtrA and 1.15 μM for human neutrophil elastase (HNE). This compound effectively inhibits the proteolytic activity associated with bacterial infections, making it a valuable tool for research into Chlamydia pathogenesis and potential therapeutic interventions. Its ability to target HtrA highlights its relevance in studies focused on bacterial virulence factors and protease biology.
Chemical Information
| Catalog Num | A77692 |
|---|---|
| M. Wt | 601.67 |
| Formula | C31H44N3O7P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 130727-21-8 |
| Synonyms | |
| SMILES | O=C(OC(C)(C)C)N[C@@H](C(C)C)C(N1[C@H](C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C(C)C)=O)CCC1)=O |
Biological Activity
| Description | JO146 is a selective inhibitor of the Chlamydia trachomatis high-temperature requirement A (CtHtrA) serine protease, exhibiting IC50 values of 21.86 μM for CtHtrA and 1.15 μM for human neutrophil elastase (HNE). This compound effectively inhibits the proteolytic activity associated with bacterial infections, making it a valuable tool for research into Chlamydia pathogenesis and potential therapeutic interventions. Its ability to target HtrA highlights its relevance in studies focused on bacterial virulence factors and protease biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
