Product Data Sheet
RWJ-58643 hydrochloride
Catalog No. A77713
RWJ-58643 hydrochloride is a selective inhibitor of serine/threonine proteases, specifically targeting β-trypsin. It has demonstrated efficacy in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at low doses, highlighting its potential for modulating allergic inflammation. Notably, administration at higher doses may lead to late eosinophilia and increased IL-5 levels. RWJ-58643 hydrochloride is valuable for research focused on understanding and managing allergic reactions through protease inhibition.
Chemical Information
| Catalog Num | A77713 |
|---|---|
| M. Wt | 482.98 |
| Formula | C20H27ClN6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 287182-52-9 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C[C@@H](C1)O)C(C)=O)NC(CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O.Cl |
Biological Activity
| Description | RWJ-58643 hydrochloride is a selective inhibitor of serine/threonine proteases, specifically targeting β-trypsin. It has demonstrated efficacy in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at low doses, highlighting its potential for modulating allergic inflammation. Notably, administration at higher doses may lead to late eosinophilia and increased IL-5 levels. RWJ-58643 hydrochloride is valuable for research focused on understanding and managing allergic reactions through protease inhibition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
