Product Data Sheet
Abz-HPGGPQ-EDDnp
Catalog No. A77752
Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts.
Chemical Information
| Catalog Num | A77752 |
|---|---|
| M. Wt | 918.91 |
| Formula | C40H50N14O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 221055-89-6 |
| Synonyms | Cathepsin K substrate |
| SMILES |
Biological Activity
| Description | Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
