Product Data Sheet
AR antagonist 11
Catalog No. A77759
AR Antagonist 11 is a selective androgen receptor (AR) antagonist with an IC50 of 0.019 μM. It also demonstrates efficacy against the ARF877L/T878A mutant with an IC50 of 1.03 μM. AR Antagonist 11 effectively inhibits LNCaP cell proliferation and reduces PSA protein expression, with an IC50 of 0.54 μM. This compound is suitable for research into prostate cancer (PCa) biology and therapeutic strategies.
Chemical Information
| Catalog Num | A77759 |
|---|---|
| M. Wt | 336.81 |
| Formula | C20H17ClN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3005979-40-5 |
| Synonyms | |
| SMILES | ClC(C=C1)=CC=C1[C@@H]([C@@H]2[C@H]3OCC2)NC4=C3C5=CC=CN=C5C=C4 |
Biological Activity
| Description | AR Antagonist 11 is a selective androgen receptor (AR) antagonist with an IC50 of 0.019 μM. It also demonstrates efficacy against the ARF877L/T878A mutant with an IC50 of 1.03 μM. AR Antagonist 11 effectively inhibits LNCaP cell proliferation and reduces PSA protein expression, with an IC50 of 0.54 μM. This compound is suitable for research into prostate cancer (PCa) biology and therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
