Product Data Sheet
PROTAC SGK3 degrader-2
Catalog No. A77835
PROTAC SGK3 degrader-2 is a selective PROTAC designed to engage SGK3 while targeting its degradation pathways. Unlike its trans counterpart, this compound possesses a cis hydroxyl group in the VH032 moiety, preventing its interaction with the VHL E3 ligase. It exhibits inhibitory effects on SGK3, SGK1, and S6K1, with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not induce SGK3 degradation. PROTAC SGK3 degrader-2 serves as an essential control reagent in research examining the specific biological effects of SGK3-PROTAC1-mediated degradation.
Chemical Information
| Catalog Num | A77835 |
|---|---|
| M. Wt | 1157.38 |
| Formula | C57H73FN10O11S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2381196-78-5 |
| Synonyms | |
| SMILES | O=C(N1[C@@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCCCCCN(CCO4)C[C@@H]4COC5=C(C=NN6)C6=NC(C7=CC=C(C=C7)NS(=O)(C8=C(C=CC(C)=C8)F)=O)=N5)=O |
Biological Activity
| Description | PROTAC SGK3 degrader-2 is a selective PROTAC designed to engage SGK3 while targeting its degradation pathways. Unlike its trans counterpart, this compound possesses a cis hydroxyl group in the VH032 moiety, preventing its interaction with the VHL E3 ligase. It exhibits inhibitory effects on SGK3, SGK1, and S6K1, with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not induce SGK3 degradation. PROTAC SGK3 degrader-2 serves as an essential control reagent in research examining the specific biological effects of SGK3-PROTAC1-mediated degradation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
