Product Data Sheet
Hirudin (54-65)
Catalog No. A77887
Hirudin (54-65) is a potent thrombin antagonist and YAP inhibitor that exhibits anticoagulatory properties. By blocking the anion binding site of thrombin, it inhibits both soluble and thrombus-bound thrombin, subsequently reducing YAP expression, nuclear translocation, and downstream signaling in vascular endothelial cells. This compound is employed in research related to liver obstructive cholestasis and liver fibrosis, as it ameliorates fibrosis symptoms, attenuates angiogenesis, and decreases inflammation and tissue hypoxia. Furthermore, Hirudin (54-65) promotes extracellular calcium influx in vascular smooth muscle, facilitating endothelium-independent contraction.
Chemical Information
| Catalog Num | A77887 |
|---|---|
| M. Wt | 1468.52 |
| Formula | C66H93N13O25 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113274-56-9 |
| Synonyms | |
| SMILES | C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CN)=O)CC(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(C)C)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC2 |
Biological Activity
| Description | Hirudin (54-65) is a potent thrombin antagonist and YAP inhibitor that exhibits anticoagulatory properties. By blocking the anion binding site of thrombin, it inhibits both soluble and thrombus-bound thrombin, subsequently reducing YAP expression, nuclear translocation, and downstream signaling in vascular endothelial cells. This compound is employed in research related to liver obstructive cholestasis and liver fibrosis, as it ameliorates fibrosis symptoms, attenuates angiogenesis, and decreases inflammation and tissue hypoxia. Furthermore, Hirudin (54-65) promotes extracellular calcium influx in vascular smooth muscle, facilitating endothelium-independent contraction. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
