Product Data Sheet
Dabigatran-d3
Catalog No. A77889
Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems.
Chemical Information
| Catalog Num | A77889 |
|---|---|
| M. Wt | 474.53 |
| Formula | C25H22D3N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246817-44-6 |
| Synonyms | BIBR 953-d3; BIBR 953ZW-d3 |
| SMILES | OC(CCN(C1=CC=CC=N1)C(C2=CC=C(C(N=C3CNC4=CC=C(C=C4)C(N)=N)=C2)N3C([2H])([2H])[2H])=O)=O |
Biological Activity
| Description | Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
