Product Data Sheet
SSR182289
Catalog No. A77930
SSR182289 is a selective and potent inhibitor of thrombin, demonstrating competitive inhibition with a Ki of 0.031 µM. This compound exhibits significant anticoagulant activity, achieving an EC100 of 96 nM in thrombin time assays, and effectively inhibits tissue factor-induced thrombin generation with an IC50 of 0.15 µM in human plasma. Additionally, SSR182289 inhibits thrombin-induced aggregation of human platelets with an IC50 of 32 nM, while showing no effect on aggregation induced by other agonists. Such properties make SSR182289 valuable for research into anticoagulation and thrombotic disorders.
Chemical Information
| Catalog Num | A77930 |
|---|---|
| M. Wt | 597.68 |
| Formula | C30H33F2N5O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 363151-21-7 |
| Synonyms | SSR182289A free base |
| SMILES | CC(NC1=C(S(=O)(N[C@H](C(N2CC/C(CC2)=C(F)/F)=O)CCCC3=NC=C(N)C=C3)=O)C=CC=C1C4=CC=CC=C4)=O |
Biological Activity
| Description | SSR182289 is a selective and potent inhibitor of thrombin, demonstrating competitive inhibition with a Ki of 0.031 µM. This compound exhibits significant anticoagulant activity, achieving an EC100 of 96 nM in thrombin time assays, and effectively inhibits tissue factor-induced thrombin generation with an IC50 of 0.15 µM in human plasma. Additionally, SSR182289 inhibits thrombin-induced aggregation of human platelets with an IC50 of 32 nM, while showing no effect on aggregation induced by other agonists. Such properties make SSR182289 valuable for research into anticoagulation and thrombotic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
