Product Data Sheet
Broussoflavonol F
Catalog No. A78127
Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways.
Chemical Information
| Catalog Num | A78127 |
|---|---|
| M. Wt | 422.47 |
| Formula | C25H26O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 162558-94-3 |
| Synonyms | |
| SMILES | O=C1C(O)=C(C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13 |
Biological Activity
| Description | Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
