Product Data Sheet
β-Sheet Breaker Peptide iAβ5
Catalog No. A78242
β-Sheet Breaker Peptide iAβ5 is a potent degrader of amyloid-β (Aβ) oligomers, specifically targeting the β-sheet conformation responsible for its aggregation in Alzheimer's disease. This peptide effectively promotes the degradation of fibrillar amyloid deposits in vivo, thereby mitigating the neurotoxic effects associated with Aβ. Additionally, β-Sheet Breaker Peptide iAβ5 can reduce the size and quantity of amyloid plaques while decreasing the activation of IL-1β-positive microglial cells surrounding these deposits. The incorporation of a hydrophobic benzyl alcohol (HBA) tag enables visual detection under acidic conditions, facilitating quantitative analysis in relevant research applications.
Chemical Information
| Catalog Num | A78242 |
|---|---|
| M. Wt | 637.72 |
| Formula | C33H43N5O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 182912-74-9 |
| Synonyms | [Pro18, Asp21] β-Amyloid (17-21) |
| SMILES |
Biological Activity
| Description | β-Sheet Breaker Peptide iAβ5 is a potent degrader of amyloid-β (Aβ) oligomers, specifically targeting the β-sheet conformation responsible for its aggregation in Alzheimer's disease. This peptide effectively promotes the degradation of fibrillar amyloid deposits in vivo, thereby mitigating the neurotoxic effects associated with Aβ. Additionally, β-Sheet Breaker Peptide iAβ5 can reduce the size and quantity of amyloid plaques while decreasing the activation of IL-1β-positive microglial cells surrounding these deposits. The incorporation of a hydrophobic benzyl alcohol (HBA) tag enables visual detection under acidic conditions, facilitating quantitative analysis in relevant research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
