Product Data Sheet
BTA-EG6
Catalog No. A78349
BTA-EG6 is a brain-penetrant binder that selectively targets aggregated amyloid-β (Aβ) peptides, exhibiting a dissociation constant (Kd) of 290 nM for Aβ1-42. This compound forms protective protein-resistive coatings that inhibit interactions between Aβ and catalase, thereby reducing neurotoxic effects. In functional assays, BTA-EG6 demonstrates protective effects against Aβ-induced cytotoxicity and oxidative stress, effectively decreasing hydrogen peroxide (H2O2) levels in neuroblastoma cells. This reagent is valuable for research focusing on Alzheimer’s disease (AD) and associated mechanisms of neurotoxicity.
Chemical Information
| Catalog Num | A78349 |
|---|---|
| M. Wt | 504.64 |
| Formula | C26H36N2O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 921193-29-5 |
| Synonyms | |
| SMILES | OCCOCCOCCOCCOCCOCCNC1=CC=C(C2=NC3=C(S2)C=C(C)C=C3)C=C1 |
Biological Activity
| Description | BTA-EG6 is a brain-penetrant binder that selectively targets aggregated amyloid-β (Aβ) peptides, exhibiting a dissociation constant (Kd) of 290 nM for Aβ1-42. This compound forms protective protein-resistive coatings that inhibit interactions between Aβ and catalase, thereby reducing neurotoxic effects. In functional assays, BTA-EG6 demonstrates protective effects against Aβ-induced cytotoxicity and oxidative stress, effectively decreasing hydrogen peroxide (H2O2) levels in neuroblastoma cells. This reagent is valuable for research focusing on Alzheimer’s disease (AD) and associated mechanisms of neurotoxicity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
