Product Data Sheet
Mca-SEVNLDAEFK(Dnp)
Catalog No. A78481
Mca-SEVNLDAEFK(Dnp) is a fluorescent substrate peptide specifically designed for the estimation of Beta-secretase 1 (BACE-1) activity. Featuring the 'Swedish' mutation of the amyloid precursor protein (APP) β-secretase cleavage site, this substrate undergoes cleavage at the -Leu-Asp- bond, releasing the highly fluorescent 7-methoxycoumarin (Mca) fragment. This release results in a significant increase in fluorescence intensity due to the removal of the quenching effect from the 2,4-dinitrophenyl (Dnp) moiety, making it a valuable tool for research applications in Alzheimer’s disease and related studies of amyloid pathology.
Chemical Information
| Catalog Num | A78481 |
|---|---|
| M. Wt | 1533.50 |
| Formula | C68H88N14O27 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1802078-31-4 |
| Synonyms | |
| SMILES | C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(O)=O)=O)=O)CCC(O)=O)=O)C)=O)CC(O)=O)=O)CC(C)C)=O)CC(N)=O)=O)C(C)C)=O)CCC(O)=O)=O)CO)=O)C=3C=4C(=CC(OC)=CC4)OC(=O)C3 |
Biological Activity
| Description | Mca-SEVNLDAEFK(Dnp) is a fluorescent substrate peptide specifically designed for the estimation of Beta-secretase 1 (BACE-1) activity. Featuring the 'Swedish' mutation of the amyloid precursor protein (APP) β-secretase cleavage site, this substrate undergoes cleavage at the -Leu-Asp- bond, releasing the highly fluorescent 7-methoxycoumarin (Mca) fragment. This release results in a significant increase in fluorescence intensity due to the removal of the quenching effect from the 2,4-dinitrophenyl (Dnp) moiety, making it a valuable tool for research applications in Alzheimer’s disease and related studies of amyloid pathology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
