Product Data Sheet
Lanabecestat hydrochloride
Catalog No. A78494
Lanabecestat hydrochloride is a potent inhibitor of beta-secretase (BACE1), primarily employed in the research of Alzheimer's disease. This compound effectively reduces amyloid beta peptide concentrations in plasma, cerebrospinal fluid, and brain tissue in a dose- and time-dependent manner. While demonstrating a reduction in Aβ neuritic plaque burden, lanabecestat has not shown clinical benefits or the ability to slow Alzheimer's disease progression. It serves as a valuable tool for studying the mechanisms underlying amyloid pathology and evaluating potential therapeutic approaches.
Chemical Information
| Catalog Num | A78494 |
|---|---|
| M. Wt | 448.99 |
| Formula | C26H29ClN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1383986-31-9 |
| Synonyms | AZD-3293 hydrochloride; LY3314814 hydrochloride |
| SMILES | CC#CC1=CC(C2=CC([C@@]34N=C(C)C(N)=N4)=C(C[C@@]53CC[C@@H](OC)CC5)C=C2)=CN=C1.Cl |
Biological Activity
| Description | Lanabecestat hydrochloride is a potent inhibitor of beta-secretase (BACE1), primarily employed in the research of Alzheimer's disease. This compound effectively reduces amyloid beta peptide concentrations in plasma, cerebrospinal fluid, and brain tissue in a dose- and time-dependent manner. While demonstrating a reduction in Aβ neuritic plaque burden, lanabecestat has not shown clinical benefits or the ability to slow Alzheimer's disease progression. It serves as a valuable tool for studying the mechanisms underlying amyloid pathology and evaluating potential therapeutic approaches. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
