Product Data Sheet
CaMKIIα-PHOTAC
Catalog No. A78524
CaMKIIα-PHOTAC is a photochemically targeted chimera designed to selectively degrade Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Upon exposure to specific wavelengths of light, this compound facilitates the ubiquitination and subsequent degradation of CaMKIIα through the endogenous proteasome pathway. Its application has demonstrated a reduction in synaptic function, notably diminishing the amplitude of evoked field excitatory postsynaptic potentials in the mouse hippocampus, thereby implicating its role in the modulation of long-term potentiation and memory processes in dendritic regions.
Chemical Information
| Catalog Num | A78524 |
|---|---|
| M. Wt | 1094.00 |
| Formula | C54H58Cl2N10O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2481744-33-4 |
| Synonyms | |
| SMILES | O=C(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)NCCCCCC(N5CCN(CCCOC6=C(OC)C=C7C(NC8=CC(OC)=C(Cl)C=C8Cl)=C(C#N)C=NC7=C6)CC5)=O |
Biological Activity
| Description | CaMKIIα-PHOTAC is a photochemically targeted chimera designed to selectively degrade Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Upon exposure to specific wavelengths of light, this compound facilitates the ubiquitination and subsequent degradation of CaMKIIα through the endogenous proteasome pathway. Its application has demonstrated a reduction in synaptic function, notably diminishing the amplitude of evoked field excitatory postsynaptic potentials in the mouse hippocampus, thereby implicating its role in the modulation of long-term potentiation and memory processes in dendritic regions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
