Product Data Sheet
Sinbaglustat
Catalog No. A78930
Sinbaglustat is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). This N-alkyl iminosugar is orally bioavailable and capable of penetrating the blood-brain barrier, making it a valuable tool for investigating central neurodegenerative disorders linked to lysosomal dysfunction. Its unique properties facilitate research into potential therapeutic strategies for conditions such as Gaucher disease and other lysosomal storage disorders.
Chemical Information
| Catalog Num | A78930 |
|---|---|
| M. Wt | 233.30 |
| Formula | C11H23NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 441061-33-2 |
| Synonyms | ACT-519276; OGT2378 |
| SMILES | O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O |
Biological Activity
| Description | Sinbaglustat is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). This N-alkyl iminosugar is orally bioavailable and capable of penetrating the blood-brain barrier, making it a valuable tool for investigating central neurodegenerative disorders linked to lysosomal dysfunction. Its unique properties facilitate research into potential therapeutic strategies for conditions such as Gaucher disease and other lysosomal storage disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
