Product Data Sheet
Glucosylceramide synthase-IN-2
Catalog No. A78936
Glucosylceramide synthase-IN-2 is a potent, orally bioavailable inhibitor of glucosylceramide synthase (GCS), demonstrating IC50 values of 15 nM for human GCS and 190 nM for mouse GCS. This compound functions as a noncompetitive inhibitor in the presence of C8-ceramide and UDP-glucose. Glucosylceramide synthase-IN-2 is particularly useful for research into Gaucher's disease, offering valuable insights into the modulation of glycosphingolipid metabolism.
Chemical Information
| Catalog Num | A78936 |
|---|---|
| M. Wt | 447.41 |
| Formula | C22H20F3N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2597958-02-4 |
| Synonyms | |
| SMILES | O=C(C1=CC=NN(C1=O)C2=C(OCC(F)(F)F)C=CC=C2)NC3=CC=C(C(C)(O)C)C=C3 |
Biological Activity
| Description | Glucosylceramide synthase-IN-2 is a potent, orally bioavailable inhibitor of glucosylceramide synthase (GCS), demonstrating IC50 values of 15 nM for human GCS and 190 nM for mouse GCS. This compound functions as a noncompetitive inhibitor in the presence of C8-ceramide and UDP-glucose. Glucosylceramide synthase-IN-2 is particularly useful for research into Gaucher's disease, offering valuable insights into the modulation of glycosphingolipid metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
