Product Data Sheet

Selegiline

Catalog No. A79002

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Selegiline is a potent, selective, and irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 51 nM and demonstrating 450-fold selectivity over MAO-A (IC50 = 23 μM). This compound is primarily researched for its neuroprotective effects and potential therapeutic applications in Parkinson's disease, Alzheimer's disease, and major depressive disorder. Its ability to influence dopaminergic pathways makes it a valuable reagent in studies related to neurodegeneration and mood disorders.
Chemical Information
Catalog NumA79002
M. Wt187.28
FormulaC13H17N
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.14611-51-9
SynonymsDeprenyl; (-)-Selegiline; (-)-Deprenyl
SMILESCN(CC#C)[C@H](C)CC1=CC=CC=C1
Biological Activity
DescriptionSelegiline is a potent, selective, and irreversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 51 nM and demonstrating 450-fold selectivity over MAO-A (IC50 = 23 μM). This compound is primarily researched for its neuroprotective effects and potential therapeutic applications in Parkinson's disease, Alzheimer's disease, and major depressive disorder. Its ability to influence dopaminergic pathways makes it a valuable reagent in studies related to neurodegeneration and mood disorders.
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