Product Data Sheet
MAO-B-IN-33
Catalog No. A79036
MAO-B-IN-33 is a potent, reversible, and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC50 of 0.021 μM for MAO-B and 26.805 μM for MAO-A, highlighting its selectivity. Its distinctive action is attributed to steric hindrance caused by differences in amino acid residues between MAO-A and MAO-B. This compound effectively inhibits cerebral MAO-B activity and demonstrates the ability to mitigate MPTP-induced dopaminergic neuronal loss in murine models. MAO-B-IN-33 shows promise for applications in Parkinson's disease research.
Chemical Information
| Catalog Num | A79036 |
|---|---|
| M. Wt | 314.35 |
| Formula | C18H19FN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2286257-25-6 |
| Synonyms | |
| SMILES | NC([C@@H]1CCN1CC2=CC=C(OCC3=CC(F)=CC=C3)C=C2)=O |
Biological Activity
| Description | MAO-B-IN-33 is a potent, reversible, and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC50 of 0.021 μM for MAO-B and 26.805 μM for MAO-A, highlighting its selectivity. Its distinctive action is attributed to steric hindrance caused by differences in amino acid residues between MAO-A and MAO-B. This compound effectively inhibits cerebral MAO-B activity and demonstrates the ability to mitigate MPTP-induced dopaminergic neuronal loss in murine models. MAO-B-IN-33 shows promise for applications in Parkinson's disease research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
