Product Data Sheet
Monoamine Oxidase B inhibitor 4
Catalog No. A79072
Monoamine Oxidase B inhibitor 4 is a selective inhibitor of human monoamine oxidase-B (hMAO-B), with an IC50 of 8.3 nM. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. Monoamine Oxidase B inhibitor 4 effectively reduces the release of pro-inflammatory cytokines such as NO, TNF-α, and IL-1β in response to LPS and Aβ1-42, while also mitigating Aβ(1-42)-induced cytotoxicity, making it a valuable tool for research in neurodegenerative diseases and neuroinflammation.
Chemical Information
| Catalog Num | A79072 |
|---|---|
| M. Wt | 324.16 |
| Formula | C15H11Cl2NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 424794-91-2 |
| Synonyms | |
| SMILES | ClC1=CC=C(NC(C2=CC=C(OCCO3)C3=C2)=O)C=C1Cl |
Biological Activity
| Description | Monoamine Oxidase B inhibitor 4 is a selective inhibitor of human monoamine oxidase-B (hMAO-B), with an IC50 of 8.3 nM. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. Monoamine Oxidase B inhibitor 4 effectively reduces the release of pro-inflammatory cytokines such as NO, TNF-α, and IL-1β in response to LPS and Aβ1-42, while also mitigating Aβ(1-42)-induced cytotoxicity, making it a valuable tool for research in neurodegenerative diseases and neuroinflammation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
